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Highest antigen sequence indentity to the following orthologs: Mouse (84%), Rat (84%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-67084. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
REEP5 (receptor expression-enhancing protein 5), also known as C5orf18, DP1, TB2 or D5S346, is a 189 amino acid multi-pass membrane protein. Thought to promote the functional cell surface expression of olfactory receptors, REEP5 belongs to the DP1 family and is encoded by a gene that maps to chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the parm of chromosome 5 leads to cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: deleted in polyposis 1; polyposis coli region hypothetical protein DP1; Polyposis locus protein 1; Protein TB2; receptor expression enhancing protein 5; Receptor expression-enhancing protein 5
基因别名: C5orf18; D5S346; DP1; REEP5; TB2; Yip2e; YOP1
UniProt ID: (Human) Q00765
Entrez Gene ID: (Human) 7905