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产品信息
PEP-1581
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 16 amino acids near the amino terminus of human TIAF.
PEP-1581 can be used as a blocking peptide with polyclonal antibody PA5-34538. For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37ºC.
靶标信息
TIAF-1 (TGFB1-induced anti-apoptotic factor 1), also known as MYO18A, is a TGFB1-induced anti-apoptotic factor that functions to inhibit the cytotoxic effects of TNF-alpha, TRADD and FADD. It localizes to the nucleus and significantly up-regulated in activated helper T lymphocytes (TH2) in chronic kidney and liver allograft rejection. Suppression of TIAF1 expression by siRNA prevents UV irradiation-mediated p53 phosphorylation and nuclear translocation. TIAF1 is essential in the p53- and WOX1-mediated cell death and shows an aggregation-dependent control of tumor progression and metastasis, and regulation of cell death.
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生物信息学
蛋白别名: 12 kDa TGF-beta-1-induced antiapoptotic factor; molecule associated with Jak-3 N-terminal; MYO18A; MYSPDZ; TGF-beta-1-induced antiapoptotic factor 1; TIAF
基因别名: MAJN; SPR210
Entrez Gene ID: (Human) 9220
