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产品信息
PEP-0624
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 14 amino acids near the amino terminus of human EVER1.
PEP-0624 can be used as a blocking peptide with polyclonal antibody PA5-20504.
靶标信息
TMC6 interacts with, and forms a complex with the zinc transporter 1, SLC30A1, and localizes to the endoplasmic reticulum, nuclear membrane and Golgi apparatus. The inactivation of the TMC6 gene has been implicated in the skin disorder epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. TMC6 encodes integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. Diseases associated with TMC6 include Epidermodysplasia Verruciformis and Superficial Mycosis.
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生物信息学
蛋白别名: epidermodysplasia verruciformis 1; Epidermodysplasia verruciformis protein 1; expressed in activated T/LAK lymphocytes; Protein LAK-4; Transmembrane channel-like protein 6
基因别名: EV1; EVER1; EVIN1; LAK-4P; TMC6
UniProt ID: (Human) Q7Z403
Entrez Gene ID: (Human) 11322
