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Invitrogen
Human TSLP Receptor (aa 152-231) Control Fragment Recombinant Protein
产品信息
RP-110016
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
YRSPFDTEWQSKQENTCNVTIEGLDAEKCYSFWVRVKAMEDVYGPDTYPSDWSEVTCWQRGEIRDACAETPTPPKPKLSK
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
1M urea/PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (28%), Rat (28%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-145100. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cytokine receptor CRL2 precusor; Cytokine receptor-like 2; Cytokine receptor-like factor 2; IL-XR; P2RY8/CRLF2 fusion; Thymic stromal lymphopoietin protein receptor; thymic stromal-derived lymphopoietin receptor; TSLP receptor; WI2-87105E3.1
基因别名: CRL2; CRLF2; CRLF2Y; ILXR; TSLPR
UniProt ID: (Human) Q9HC73
Entrez Gene ID: (Human) 64109
