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产品信息
PHC1615
应用
建议稀释比
已发表文章
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
Human alpha-Defensin 1 recombinant protein contains 30 amino acids
分子量
3.4 kDa
分类
Recombinant
类型
Protein
纯度
≥98% by SDS-PAGE and HPLC
内毒素浓度
<0.1 ng/µg
活性
ED50 = 1 - 10 ng/mL; determined by the dose-dependent chemotaxis of immature dendritic cells.
偶联物
形式
Lyophilized
纯化类型
purified
内含物
no preservative
保存条件
-20°C
运输条件
Wet ice (domestic); Wet or Dry ice (international)
产品详细信息
Carrier-Free
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute NP-1 in sterile, distilled water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2°C to 8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein, such as 0.1% BSA and store in working aliquots at -20°C to -80°C.
Storage: The lyophilized protein is stable at room temperature for 1 month, but should be kept at -20°C for long term storage. Working aliquots stored with a carrier protein are stable for at least 3 months at -20°C to -80°C. Avoid repeated freeze/thaw cycles.
靶标信息
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
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生物信息学
蛋白别名: Defensin, alpha 1; defensin, alpha 1, myeloid-related sequence; defensin, alpha 2; HNP-1; HP-1; myeloid-related sequence; Neutrophil defensin 1
基因别名: DEF1; DEFA1; DEFA1B; DEFA2; HNP-1; HP-1; HP1; MRS
UniProt ID: (Human) P59665
Entrez Gene ID: (Human) 1667
