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产品信息
450-58-20UG
产品规格
种属
Mouse
Expression System
E. coli
氨基酸序列
AGTRSSRART TDARGCRLRS QLVPVSALGL GHSSDELIRF RFCSGSCRRA RSQHDLSLAS LLGAGALRSP PGSRPISQPC CRPTRYEAVS FMDVNSTWRT VDHLSATACG CLG
分子量
12.1 kDa
分类
Recombinant
类型
Protein
纯度
≥ 97% by SDS-PAGE gel and HPLC analyses.
内毒素浓度
<1 EU/µg
活性
Determined by the dose-dependent stimulation of the proliferation of SH-SY5Y cells. The expected ED50 for this effect is 0.1-0.5 ug/ml.
偶联物
形式
Lyophilized
纯化类型
purified
内含物
no preservative
保存条件
-20°C
运输条件
Ambient
产品详细信息
Recombinant Murine Artemin is a disulfide-linked homodimer formed by two identical 113 amino acid subunits with a calculated molecular weight of 24.2 kDa.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
靶标信息
The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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