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PEP-075 is a 13 amino acid synthetic peptide whose sequence corresponds to residues 582-594 of mouse BMAL-1 with an amino terminal cysteine added for carrier protein conjugation. The sequence of this peptide is (amino to carboxy terminus): (C)-D582-M-I-D-N-D-Q-G-S-S-S-P-S594
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse BMAL-1, catalog # PA1-523. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。