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产品信息
RP-88258
产品规格
种属
Mouse
Expression System
HEK293 cells
氨基酸序列
Mouse SLAMF7, amino acids Met1-Gly224 (Accession # NP_653122.2) with a C-terminal His-tag
标签
His-tag
分子量
35-50 kDa
分类
Recombinant
类型
Protein
纯度
>95% as determined by SDS-PAGE.
内毒素浓度
<1.0 EU/µg
偶联物
形式
Lyophilized
纯化类型
purified
保存液
PBS, pH 7.4, with 5% mannitol, 5% trehalose, 0.01% Tween 80
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
It is recommended that the protein be aliquoted for optimal storage.
It is recommended that sterile water (400 µL) be added to the vial to prepare a stock solution of 2.5 mg/mL.
Concentration is measured by UV.
靶标信息
SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro). SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. The isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD319; Leukocyte cell-surface antigen; Novel Ly9; SLAM family member 7
基因别名: 19A; 19A24; 4930560D03Rik; CRACC; CS1; Slamf7
UniProt ID: (Mouse) Q8BHK6
Entrez Gene ID: (Mouse) 75345
