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产品信息
PEP-200
产品规格
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-200 is a 18 amino acid synthetic peptide whose sequence is derived from mouse Fe65 protein. The sequence of this peptide is (amino to carboxy terminus): Synthetic Peptide: P (352)-Q-E-E-E-K-L-S-Q-R-N-A-N-P-G-I-K-C (369).
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product, Fe65 catalog # PA1-752. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
靶标信息
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein, transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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