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产品信息
RP-88252
产品规格
种属
Mouse
Expression System
HEK293 cells
氨基酸序列
Mouse PDGFRA, amino acids Met1-Ala528 (Accession # NP_001334647.1) with a C-terminal His-tag
标签
His-tag
分子量
57.87 kDa
分类
Recombinant
类型
Protein
纯度
>95% as determined by SDS-PAGE.
内毒素浓度
<1.0 EU/µg
活性
Measured by its binding ability in a functional ELISA. Immobilized Mouse PDGFRA His at 2 µg/ml (100 µL/well) can bind Cynomolgus PDGF-B mFc, the EC50 of Cynomolgus PDGF-B mFc is 150-700 ng/mL.
偶联物
形式
Lyophilized
纯化类型
purified
保存液
PBS, pH 7.4, with 5% mannitol, 5% trehalose, 0.01% Tween 80
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
It is recommended that the protein be aliquoted for optimal storage.
Reconstituted with sterile deionized water to 0.25 mg/mL.
Concentration is measured by UV.
靶标信息
PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha); Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a; MGC74795; OTTHUMP00000218656; PDGF A-chain; PDGF alpha chain; PDGF Receptor alpha; PDGF subunit A; PDGF-1; PDGF-R-alpha; pdgfr-a; PDGFR-alpha; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor alpha
基因别名: AI115593; CD140a; Pdgfr-2; Pdgfra
UniProt ID: (Mouse) P26618
Entrez Gene ID: (Mouse) 18595
