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产品信息
PEP-064
产品规格
种属反应
Rat
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
purified
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-064 is a 10 amino acid synthetic phospho-peptide whose sequence corresponds to residues 24-33 of rat AA-NAT. The sequence of this peptide is (amino to carboxy terminus): C24-Q-R-R-H-T (P)-L-P-A-S33
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and Phospho-Thr29 AA-NAT, catalog # PA1-761. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
靶标信息
Arylalkylamine N-Acetyltransferase (AANAT) is the penultimate enzyme is melatonin synthesis. Hormonal melatonin has been implicated in sleep and circadian clock function. Large changes in the abundance of AANAT are believed to be responsible for the large day/night rhythms in melatonin synthesis in the pineal gland and retina. Most research shows that AANAT activity is regulated by controlling the steady-state levels of the protein. Recent research, however, suggests that another mechanism may also play a role in controlling melatonin production without altering AANAT protein and activity. This mechanism may explain the sudden physiological increase in circulating melatonin observed at the onset of the dark period in humans.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AA-NAT; Aralkylamine N-acetyltransferase; arylakylamine N-acetyltransferase; Arylalkylamine N - acetyltransferase (Serotonin N - acetyltransferase); arylalkylamine N-acetyltransferase; Seretonin N-acetyltransferase; Serotonin acetylase; Serotonin N-acetyltransferase
基因别名: AA-NAT; Aanat; Nat4; Snat
UniProt ID: (Rat) Q64666
Entrez Gene ID: (Rat) 25120
