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产品规格
检测灵敏度
Lot-specific
测定范围
Lot-specific
手工操作时间
1 hr 45 min
总时间
24 hr 30 min
均相（无需洗涤）
No
检测仪器
Colorimetric Microplate Reader
产品规格
10 x 96 Tests
产品成分
This Human IL-1 alpha ELISA Kit includes Capture Antibody, Detection Antibody, Protein Standard, and HRP-conjugate. The HRP-conjugate is packaged separately.
储存
Refer to product documentation for component specific storage temperature.
蛋白名称
IL-1 alpha
蛋白家族
Growth Factors & Receptors
均相（无需洗涤）
Human
检测试剂盒格式
ELISA Development Kit
检测抗体结合物
Biotin
标签或染料
HRP
关于本试剂盒
900-T11K consists of: 900-T11 (capture antibody, detection antibody, and protein standard), and HRP-17UL (streptavidin HRP-conjugate).
Human IL-1 alpha TMB ELISA Development Kit contains the key components required for the quantitative measurement of natural and/or recombinanthuman IL-1 alpha in a sandwich ELISA format. Human IL-1 alpha TMB ELISA Development Kit contains enough material to assay the target cytokine in at least 1,000 ELISA plate wells.
The TMB ELISA Buffer Kit (Product # 900-T00), sold separately, is recommended to be used in conjunction with this TMB ELISA Development Kit for optimal performance. This buffer kit contains all the necessary components to assay ten 96-well ELISA plates (included) and contains detailed handling instructions.
靶标信息
IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 alpha is coded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 beta. IL1A is located on the q arm on chromosome 2 at position 13. IL-1 alpha plays an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. IL-1 alpha activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. Further, IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury and induces apoptosis. The IL1A gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL1 alpha regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL-1 alpha can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-1 alpha are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
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生物信息学
基因别名 : IL-1A, IL1, IL1-ALPHA, IL1A, IL1F1
基因ID : (Human) 3552
基因符号 : IL1A
蛋白别名 : CTLA8, IL17, interleukin 17, Interleukin-17A, IL 1α, IL1α, ILN, Interleukin, Interleukin1 alpha, RP23-160G19.8, IL 1 a, Hematopoietin-1, IL-1 alpha, interleukin 1, alpha, Interleukin-1 alpha, preinterleukin 1 alpha, pro-interleukin-1-alpha
UniProt ID (Human) P01583
