Search Thermo Fisher Scientific
产品规格
检测灵敏度
Lot-specific
测定范围
Lot-specific
手工操作时间
1 hr 45 min
总时间
24 hr 30 min
均相（无需洗涤）
No
检测仪器
Colorimetric Microplate Reader
产品规格
10 x 96 Tests
产品成分
This Human CCL4 ELISA Kit includes Capture Antibody, Detection Antibody, Protein Standard, and HRP-conjugate. The HRP-conjugate is packaged separately.
储存
Refer to product documentation for component specific storage temperature.
蛋白名称
CCL4
蛋白家族
Growth Factors & Receptors
均相（无需洗涤）
Human
检测试剂盒格式
ELISA Development Kit
检测抗体结合物
Biotin
标签或染料
HRP
关于本试剂盒
900-T36K consists of: 900-T36 (capture antibody, detection antibody, and protein standard), and HRP-17UL (streptavidin HRP-conjugate).
Human CCL4 TMB ELISA Development Kit contains the key components required for the quantitative measurement of natural and/or recombinanthuman CCL4 in a sandwich ELISA format. Human CCL4 TMB ELISA Development Kit contains enough material to assay the target cytokine in at least 1,000 ELISA plate wells.
The TMB ELISA Buffer Kit (Product # 900-T00), sold separately, is recommended to be used in conjunction with this TMB ELISA Development Kit for optimal performance. This buffer kit contains all the necessary components to assay ten 96-well ELISA plates (included) and contains detailed handling instructions.
靶标信息
CCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the intercrine beta (chemokine CC) family. Functionally, CCL4 is involved in chemotactic and proinflammatory effects, and homeostasis. CCL4 is produced by macrophages upon stimulation by bacterial endotoxins. CCL4 recruits and stimulates various inflammatory cells at sites of inflammation. CCL4 is produced by lymphocytes, macrophages and dendritic cells. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ, with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells. CCL4 binds with high affinity to CCR5 receptors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
基因别名 : ACT2, AT744.1, CCL4, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4
基因ID : (Human) 6351
基因符号 : CCL4
蛋白别名 : ACT-2, C-C motif chemokine 4, chemokine (C-C motif) ligand 4, G-26 T-lymphocyte-secreted protein, HC21, LAG-1, Lymphocyte activation gene 1 protein, Macrophage inflammatory protein 1-beta, MGC104418, MGC126025, MGC126026, MIP1-beta, RP23-320E6.8, MIP1beta, MIP-1-beta, MIP-1-beta(1-69), MIP-1-beta(3-69), PAT 744, Protein H400, secreted protein G-26, SIS-gamma, small inducible cytokine A4 (homologous to mouse Mip-1b), Small-inducible cytokine A4, T-cell activation protein 2
UniProt ID (Human) P13236
