Search Thermo Fisher Scientific
Human SOX17 quantitates human SOX17 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human SOX17.
SOX17 (transcription factor SOX-17) belongs to the SRY-related HMB box family of transcription factors. It acts as a transcription regulator that binds target promoter DNA and bends the DNA. It binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. SOX17 modulates transcriptional regulation via WNT3A and inhibits Wnt signaling. It promotes degradation of activated CTNNB1. SOX17 plays an essential role in the regulation of embryonic development and is required for normal looping of the embryonic hear tube and for normal development of the definitive gut endoderm. Mutations in the gene can result in vesicoureteral reflux.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
基因别名 : SOX17, VUR3
基因ID : (Human) 64321
基因符号 : SOX17
蛋白别名 : SRY (sex determining region Y)-box 17, SRY box 17, SRY-related HMG-box transcription factor SOX17, Transcription factor SOX-17
UniProt ID (Human) Q9H6I2