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CD355 (CRTAM) Antibody (12-3559-42) in Flow
Normal human peripheral blood cells were unstimulated (left) or stimulated for 4 hours with the Cell Stimulation Cocktail (Product # 00-4970-93) (right). Cells were then stained with CD8 Monoclonal Antibody, APC (Product # 17-0088-42) and CD355 Monoclonal Antibody, PE. Cells in the lymphocyte gate were used for analysis.
产品信息
12-3559-42
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
Cr24.1
偶联物
激发/发射光谱
565/576 nm
查看光谱
形式
Liquid
浓度
5 µL/Test
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 0.2% BSA
内含物
0.09% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2815047
产品详细信息
Description: This monoclonal antibody Cr24.1 reacts with human CD355, also known as Class-I MHC-restricted T-cell-associated molecule (CRTAM). CD355 usually exists as a homodimer, however, it forms a heterodimer with its ligand Necl-2. CD355 is transiently expressed by activated NK, NKT, gamma delta T, and CD8+ T cells. CD355 is also expressed by Purkinje neurons. Human CD355 is involved in immunosurveillance of cancer cells, gamma delta T cell survival, cell polarity, retention of lymphocytes in lymph nodes, promotion of cytotoxicity in NK cells, and IFN gamma secretion from CD8+ T cells. Cr24.1 has been reported to have antagonist activity.
Applications Reported: This CR24.1 antibody has been reported for use in flow cytometric analysis.
Applications Tested: This CR24.1 antibody has been pre-diluted and tested by flow cytometric analysis of stimulated normal human peripheral blood cells. This may be used at 5 µL (0.5 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser
靶标信息
The CRTAM gene is upregulated in CD4-positive and CD8-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
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生物信息学
蛋白别名: CD355; CD355 antigen; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; Class-I MHC-restricted T-cell-associated molecule; cytotoxic and regulatory T cell molecule; Cytotoxic and regulatory T-cell molecule
基因别名: CD355; CRTAM
UniProt ID: (Human) O95727
Entrez Gene ID: (Human) 56253
T cell mediated cytotoxicity
detection of tumor cell
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
cell recognition
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of cytokine secretion
regulation of immune response
activated T cell proliferation
detection of stimulus
