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SNAP25 Antibody (701991) in ICC/IF
For immunofluorescence analysis, PC12 cells were fixed and permeabilized for detection of endogenous SNAP25 using Anti-SNAP25 Recombinant Rabbit Monoclonal Antibody (Product # 701991, 5 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Nuclei (blue) is stained using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938) and cytoskeletal F-actin (red) staining using Rhodamine Phalloidin (Product # R415, 1:300) Panel a-d) shows representat... View More
产品信息
701991
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1H7L4
抗原
Peptides corresponding to human SNAP25 (1) aa37-aa55 2) aa168-aa186)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2716878
产品详细信息
This antibody is predicted to react with Monkey, Horse, Pig, Rabbit
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
SNAP25 is a t-SNARE involved in the molecular regulation of neurotransmitter release. It may play a role in the synaptic function of specific neuronal systems. SNAP25 associates with proteins involved in vesicle docking and membrane fusion. It also regulates plasma membrane recycling through its interaction with CENPF. Mutations in the gene can results in myasthenic syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ALMS1; blind drunk; CG17676; CG17884; CG40452; Dmel CG40452; Dmel_CG40452; FLJ23079; HGNC:11132; resistance to inhibitors of cholinesterase 4 homolog; SNAP 25; SNAP-25; snp25; SUP; Super protein; Synaptosomal-associated 25 kDa protein; Synaptosomal-associated protein 25; synaptosomal-associated protein, 25 kDa; synaptosomal-associated protein, 25kDa; synaptosome associated protein 25kDa
基因别名: bA416N4.2; Bdr; CMS18; dJ1068F16.2; GENA70; RIC-4; RIC4; SEC9; SNAP; SNAP-25; SNAP-25a; SNAP-25B; SNAP25; sp; SUP
UniProt ID: (Human) P60880, (Rat) P60881, (Mouse) P60879
Entrez Gene ID: (Human) 6616, (Rat) 25012, (Mouse) 20614
neurotransmitter uptake
chemical synaptic transmission
neurotransmitter secretion
locomotory behavior
associative learning
regulation of neuron projection development
glutamate secretion
synaptic vesicle exocytosis
synaptic vesicle docking
synaptic vesicle priming
synaptic vesicle fusion to presynaptic active zone membrane
regulation of insulin secretion
long-term synaptic potentiation
exocytosis
axonogenesis
long-term memory
endosomal transport
growth hormone secretion
sleep
positive regulation of insulin secretion
positive regulation of hormone secretion
calcium ion-regulated exocytosis of neurotransmitter
regulation of synapse assembly
regulation of establishment of protein localization
potassium ion transmembrane transport
regulation of ion transmembrane transport
