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C17orf96 Antibody (703052) in ICC/IF
For immunofluorescence analysis, HEK-293 cells were fixed and permeabilized for detection of endogenous C17orf96 using Anti-C17orf96 Recombinant Rabbit Monoclonal Antibody (Product # 703052, 1:100 dilution) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of C17orf96 protein (green), Panel b) is stained for nuclei (blue) using ProLong™ Diamond Antifade Mountant with ... View More
产品信息
703052
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5H7L8
抗原
Peptides corresponding to human C17orf96 [aa130-aa148, aa360-aa379]
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2809223
产品详细信息
This antibody is predicted to react with Monkey, Pig, Cat, Dog.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Elongin BC and Polycomb repressive complex 2-associated protein (EPOP) also know as C17ORF96 is a scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex. It is required to fine tune the transcriptional status of polycomb group (PcG) target genes in embryonic stem cells (ESCs). C17ORF96 also plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression of PcG target genes. It acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. C17ORF96 also has interacts with USP7 and promotes deubiquitination of H2B at promoter sites.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Elongin BC and Polycomb repressive complex 2-associated protein; Embryonic stem cell-specific PRC2 subunit p48; ES cell-specific PRC2 subunit p48; proline rich 28; Proline-rich protein 28; uncharacterized protein C17orf96 homolog; Uncharacterized protein ENSP00000317905
基因别名: AA409164; AI413509; AW539173; C17orf96; E13; EPOP; esPRC2p48; PRR28
UniProt ID: (Human) A6NHQ4, (Mouse) Q7TNS8
Entrez Gene ID: (Human) 100170841, (Mouse) 103551
