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产品信息
A33552
产品规格
种属
Human
Expression System
Insect cells
氨基酸序列
Full length
标签
GST-tag
分子量
73.6 kDa
分类
Recombinant
类型
Protein
偶联物
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
50mM tris HCl, pH 7.5, with 0.25mM DTT, 0.1mM EDTA, 150mM NaCl, 10mM glutathione, 25% glycerol, 0.1mM PMSF
内含物
no preservative
保存条件
-80° C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
This CSNK1E (CK1 epsilon) R178C recombinant human protein (full length) was expressed in insect cells.
CSNK1E (CK1 epsilon) R178C recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the Z'-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
Protein Form: Full Length, Recombinant, Active
The gene accession number for CSNK1E (CK1 epsilon) [R178C] is NP_001885.1.
靶标信息
CSNK1E serine/threonine kinase is a member of the CK1 family which plays an important role in diverse cell processes, including DNA replication and repair. CSNK1E is a regulator of Yes-associated protein (YAP) transcription coactivator, which is a key regulator of organ size and a candidate human oncogene. CSNK1E is activated by CCK2R and then phosphorylates PKD2 at Ser244. Phosphorylation of PKD2 leads to its nuclear accumulation and efficient phosphorylation of nuclear PKD2 substrates in human gastric cancer cells. CSNK1E can phosphorylate topoisomerase (topo) II alpha at serine-1106 and this regulates the enzyme activity and sensitivity to topo II-targeted drugs.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: casein kinase 1, epsilon; Casein kinase I isoform epsilon; CK1; CKI-epsilon; CKIe
基因别名: CKIepsilon; CSNK1E; HCKIE
UniProt ID: (Human) P49674
Entrez Gene ID: (Human) 1454
