Product References
Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Steuer EL,Kemper LJ,Hlynialuk CJW,Leinonen-Wright K,Montonye ML,Lapcinski IP,Forster CL,Ashe KH,Liu P
MA5-12805 was used in Western Blotting to demonstrate that htau transgene expression occurs primarily in the forebrain at similar levels in rT2 and rT3 mice.
Wed Jun 08 00:00:00 UTC 2022
Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction.
eLife
Zhang X,Zou L,Meng L,Xiong M,Pan L,Chen G,Zheng Y,Xiong J,Wang Z,Duong DM,Zhang Z,Cao X,Wang T,Tang L,Ye K,Zhang Z
MA5-12805 was used in Immunohistochemistry to demonstrate that Amphiphysin I mediates tau phosphorylation and synaptic dysfunction in Alzheimer's disease.
Fri May 21 00:00:00 UTC 2021
Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction.
eLife
Zhang X,Zou L,Meng L,Xiong M,Pan L,Chen G,Zheng Y,Xiong J,Wang Z,Duong DM,Zhang Z,Cao X,Wang T,Tang L,Ye K,Zhang Z
MA5-12805 was used in Immunohistochemistry to demonstrate that Amphiphysin I mediates tau phosphorylation and synaptic dysfunction in Alzheimer's disease.
Fri May 21 00:00:00 UTC 2021
Memantine Differentially Regulates Tau Phosphorylation Induced by Chronic Restraint Stress of Varying Duration in Mice.
Neural plasticity
Liu Y,Cao L,Zhang X,Liang Y,Xu Y,Zhu C
MA5-12805 was used in Western Blotting to investigate the effects of memantine, an uncompetitive N-methyl-D-aspartate receptor antagonist, on chronic restraint stress- induced tau phosphorylation in mice.
Mon May 13 00:00:00 UTC 2019
A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients.
Acta neuropathologica communications
Liu P,Smith BR,Huang ES,Mahesh A,Vonsattel JPG,Petersen AJ,Gomez-Pastor R,Ashe KH
MA5-12805 was used in Western Blotting to identify the presence of Δtau314 proteins in the striatum and prefrontal cortex of human subjects and showed that in both structires levels of Casp2 and Δtau314 proteins correlate well and both are higher in Huntington's disease patients than non-HD individuals.
Tue Jul 30 00:00:00 UTC 2019
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nature communications
Zhang Z,Obianyo O,Dall E,Du Y,Fu H,Liu X,Kang SS,Song M,Yu SP,Cabrele C,Schubert M,Li X,Wang JZ,Brandstetter H,Ye K
MA512805 was used in western blot to evaluate the efficacy of an orally bioactive and brain permeable gamma-secretase inhibitor in a mouse model of Alzheimer's disease
Mon Mar 27 00:00:00 UTC 2017
Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi.
Age (Dordrecht, Netherlands)
Du LL,Xie JZ,Cheng XS,Li XH,Kong FL,Jiang X,Ma ZW,Wang JZ,Chen C,Zhou XW
MA5-12805 was used in western blot to study the protective effects of pharmacological SIRT1 activation against tau hyperphosphorylation and memory deficits in a rat model of brain insulin resistance
Tue Apr 01 00:00:00 UTC 2014
Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease.
Neurobiology of aging
Yu G,Yan T,Feng Y,Liu X,Xia Y,Luo H,Wang JZ,Wang X
MA5-12805 was used in western blot to study the role of CKII-mediated Ser9 phosphorylation in the cytoplasmic retention of SET in Alzheimer's disease
Mon Jul 01 00:00:00 UTC 2013
Nmnat2 attenuates Tau phosphorylation through activation of PP2A.
Journal of Alzheimer's disease : JAD
Cheng XS,Zhao KP,Jiang X,Du LL,Li XH,Ma ZW,Yao J,Luo Y,Duan DX,Wang JZ,Zhou XW
MA5-12805 was used in western blot to study the ability of Nmnat2 overexpression to activate PP2A and reduce levels of tau phosphorylation
Mon Dec 09 00:00:00 UTC 2013
Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400.
FEBS letters
Cameron A,Giacomozzi B,Joyce J,Gray A,Graham D,Ousson S,Neny M,Beher D,Carlson G,O'Moore J,Shearman M,Hering H
MA5-12805 was used in immunoprecipitation and western blot to study a site-specific rabbit monoclonal antibody that recognozes serine 400 O-GlcNAcylated tau
Fri Nov 15 00:00:00 UTC 2013
Overexpression of RCAN1 isoform 4 in mouse neurons leads to a moderate behavioral impairment.
Neurological research
Bhoiwala DL,Koleilat I,Qian J,Beyer B,Hushmendy SF,Mathew A,Bhoiwala DL,Ferland RJ,Crawford DR
MA5-12805 was used in western blot to study the effect of transgenic overexpression of human RCAN1 on cognitive performance in young and adult mice
Tue Jan 01 00:00:00 UTC 2013
Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-β peptide injection in rats.
PloS one
Zussy C,Brureau A,Keller E,Marchal S,Blayo C,Delair B,Ixart G,Maurice T,Givalois L
MA5-12805 was used in western blot to study the ability of a single intracerebroventricular injection of soluble oligomers of a beta-amyloid fragment to induce Alzhiemers's disease pathology in a rat model
Tue Aug 20 00:00:00 UTC 2013
Glycation exacerbates the neuronal toxicity of β-amyloid.
Cell death & disease
Li XH,Du LL,Cheng XS,Jiang X,Zhang Y,Lv BL,Liu R,Wang JZ,Zhou XW
MA5-12805 was used in western blot to study the increased neuronal toxicity of glycated beta-amyloid
Thu Jun 13 00:00:00 UTC 2013
NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss.
Cell death & disease
Tackenberg C,Grinschgl S,Trutzel A,Santuccione AC,Frey MC,Konietzko U,Grimm J,Brandt R,Nitsch RM
MA5-12805 was used in western blot to study the effect of the subunit composition of NMDA receptors on neurodegeneration and synaptic loss induced by beta-amyloid
Thu Apr 25 00:00:00 UTC 2013
Expression of the hyperphosphorylated tau attenuates ER stress-induced apoptosis with upregulation of unfolded protein response.
Apoptosis : an international journal on programmed cell death
Liu XA,Song J,Jiang Q,Wang Q,Tian Q,Wang JZ
MA5-12805 was used in immunocytochemistry and western blot to study the role of an upregulation of the unfolded protein response in the mechanism by which tau hyperphosphorylation protects against apoptosis induced by ER stress
Mon Oct 01 00:00:00 UTC 2012
AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation.
Neurobiology of aging
Li XH,Lv BL,Xie JZ,Liu J,Zhou XW,Wang JZ
MA5-12805 was used in western blot to study the mechanism by which advanced glycation end-products induce tau hyperphosphorylation and memory impairment
Sun Jul 01 00:00:00 UTC 2012
Methylglyoxal induces tau hyperphosphorylation via promoting AGEs formation.
Neuromolecular medicine
Li XH,Xie JZ,Jiang X,Lv BL,Cheng XS,Du LL,Zhang JY,Wang JZ,Zhou XW
MA5-12805 was used in western blot to study the mechanism by which methylglyoxal induces tau hyperphosphorylation
Sat Dec 01 00:00:00 UTC 2012
Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats.
Behavioural brain research
Lin D,Cao L,Wang Z,Li J,Washington JM,Zuo Z
Published figure using Tau monoclonal antibody (Product # MA5-12805) in Western Blot
Sat Mar 17 00:00:00 UTC 2012
Enriched environment prevents cognitive impairment and tau hyperphosphorylation after chronic cerebral hypoperfusion.
Current neurovascular research
Yao ZH,Zhang JJ,Xie XF
MA5-12805 was used in western blot to study the effect of an enriched environment on cognitive impairment and tau hyperphosphorylation in chronic cerebral hypoperfusion
Wed Aug 01 00:00:00 UTC 2012
A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease.
Toxicological sciences : an official journal of the Society of Toxicology
Li G,Cai F,Yan W,Li C,Wang J
MA5-12805 was used in western blot to study MCLR-induced neurotoxicity using proteomics
Fri Jun 01 00:00:00 UTC 2012
Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease.
Journal of neuroinflammation
Tweedie D,Ferguson RA,Fishman K,Frankola KA,Van Praag H,Holloway HW,Luo W,Li Y,Caracciolo L,Russo I,Barlati S,Ray B,Lahiri DK,Bosetti F,Greig NH,Rosi S
MA5-12805 was used in western blot to study the effects of an inhibitor of TNF-alpha production in animal models of neuroinflammation and Alzheimer's disease
Tue May 29 00:00:00 UTC 2012
Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation.
Neurobiology of aging
Hundelt M,Fath T,Selle K,Oesterwind K,Jordan J,Schultz C,Götz J,von Engelhardt J,Monyer H,Lewejohann L,Sachser N,Bakota L,Brandt R
MA5-12805 was used in western blot to study the role of hyperphosphorylation of tau in Alzheimer's disease using a novel transgenic mouse model
Wed Jun 01 00:00:00 UTC 2011
Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration.
Neurobiology of aging
Kulic L,Wollmer MA,Rhein V,Pagani L,Kuehnle K,Cattepoel S,Tracy J,Eckert A,Nitsch RM
MA5-12805 was used in western blot to study the interaction between mitochondrial dysfunction and tau pathology in a novel mouse model
Sat Oct 01 00:00:00 UTC 2011
Inhibition of glycogen synthase kinase-3β by Angelica sinensis extract decreases β-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons.
Journal of neuroscience research
Zhang Z,Zhao R,Qi J,Wen S,Tang Y,Wang D
MA5-12805 was used in western blot to study the inhibition of GSK3-beta by a traditional Chinese medicine and its effects on beta-amyloid toxicity and tau phosphorylation in cortical neurones
Tue Mar 01 00:00:00 UTC 2011
Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation in HEK293 cells.
Journal of Alzheimer's disease : JAD
Yu G,Li Y,Tian Q,Liu R,Wang Q,Wang JZ,Wang X
MA5-12805 was used in western blot to study the mechanism by which berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation
Mon Sep 19 00:00:00 UTC 2011
Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats.
Journal of Alzheimer's disease : JAD
Wei W,Liu YH,Zhang CE,Wang Q,Wei Z,Mousseau DD,Wang JZ,Tian Q,Liu GP
MA5-12805 was used in western blot to study the role of vitamin B12 in preventing tau phosphorylation and cognition decline in aged rats
Mon Aug 20 00:00:00 UTC 2012
Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody.
Amino acids
Yuzwa SA,Yadav AK,Skorobogatko Y,Clark T,Vosseller K,Vocadlo DJ
MA5-12805 was used in western blot to investigate the glycosylation of tau protein
Tue Mar 01 00:00:00 UTC 2011
AMPK activation inhibits apoptosis and tau hyperphosphorylation mediated by palmitate in SH-SY5Y cells.
Brain research
Kim J,Park YJ,Jang Y,Kwon YH
MA5-12805 was used in western blot to study the role of AMPK activation in inhibiting palmitate-induded apoptosis and tau hyperphosphorylation in SH-SY5Y cells
Tue Oct 18 00:00:00 UTC 2011
A comparative study of Lrrk2 function in primary neuronal cultures.
Parkinsonism & related disorders
Dächsel JC,Behrouz B,Yue M,Beevers JE,Melrose HL,Farrer MJ
MA5-12805 was used in immunocytochemistry to investigate the role of Lrrk2 in dendritic neuronal arborization
Wed Dec 01 00:00:00 UTC 2010
Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2.
Journal of Alzheimer's disease : JAD
Liu XA,Liao K,Liu R,Wang HH,Zhang Y,Zhang Q,Wang Q,Li HL,Tian Q,Wang JZ
MA5-12805 was used in western blot to study the mechanism by which tau dephosphorylation facilitates apoptosis
Wed May 05 00:00:00 UTC 2010
LiCl attenuates thapsigargin-induced tau hyperphosphorylation by inhibiting GSK-3β in vivo and in vitro.
Journal of Alzheimer's disease : JAD
Fu ZQ,Yang Y,Song J,Jiang Q,Lin ZC,Wang Q,Zhu LQ,Wang JZ,Tian Q
MA5-12805 was used in western blot to investigate the influence of endoplasmic reticulum stress on tau phosphorylation
Tue Jan 31 00:00:00 UTC 2012
Protective effect of isoflavones against homocysteine-mediated neuronal degeneration in SH-SY5Y cells.
Amino acids
Park YJ,Jang Y,Kwon YH
MA5-12805 was used in western blot to study the mechanism for the protective effect of isoflavones on honmocysteine-mediated neuronal degeneration in SH-SY5Y cells
Sun Aug 01 00:00:00 UTC 2010
Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain.
Journal of Alzheimer's disease : JAD
Zhang JY,Peng C,Shi H,Wang S,Wang Q,Wang JZ
MA5-12805 was used in western blot to study the mechanism by which inhibition of autophagy promotes proteolysis of tau in rat brain
Fri Mar 27 00:00:00 UTC 2009
Isoflavones prevent endoplasmic reticulum stress-mediated neuronal degeneration by inhibiting tau hyperphosphorylation in SH-SY5Y cells.
Journal of medicinal food
Park YJ,Jang YM,Kwon YH
MA5-12805 was used in western blot to investigate the effect of isoflavone on tau phosphorylation in neurons
Mon Jun 01 00:00:00 UTC 2009
Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms.
Neurobiology of aging
Liu GP,Zhang Y,Yao XQ,Zhang CE,Fang J,Wang Q,Wang JZ
MA5-12805 was used in western blot to study the mechanisms by which GSK-3 activation inhibits protein phosphatase-2A
Mon Sep 01 00:00:00 UTC 2008
Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A.
Neurochemical research
Liu XA,Zhu LQ,Zhang Q,Shi HR,Wang SH,Wang Q,Wang JZ
MA5-12805 was used in western blot to study the effect of estradiol on PKA-induced tau441 hyperphosphorylation in stably transfected HEK293 cells
Mon Sep 01 00:00:00 UTC 2008
17beta-estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner.
Journal of neural transmission (Vienna, Austria : 1996)
Shi HR,Zhu LQ,Wang SH,Liu XA,Tian Q,Zhang Q,Wang Q,Wang JZ
MA5-12805 was used in western blot to study the role of Akt in the attenuation of GSK-3beta activity and tau hyperphosphorylation by 17beta-estradiol
Sun Jun 01 00:00:00 UTC 2008
Effects of tau phosphorylation on proteasome activity.
FEBS letters
Ren QG,Liao XM,Chen XQ,Liu GP,Wang JZ
MA5-12805 was used in western blot to study the effects of tau phosphorylation on proteasome activity
Tue Apr 03 00:00:00 UTC 2007
The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells.
Journal of molecular medicine (Berlin, Germany)
Esposito G,De Filippis D,Carnuccio R,Izzo AA,Iuvone T
MA5-12805 was used in western blot to investigate the mechanism of tau phosphorylation regulation by cannabidiol in PC12 cells
Wed Mar 01 00:00:00 UTC 2006
The involvement of glycogen synthase kinase-3 and protein phosphatase-2A in lactacystin-induced tau accumulation.
FEBS letters
Ren QG,Liao XM,Wang ZF,Qu ZS,Wang JZ
MA5-12805 was used in western blot to study the involvement of GSK-3 and protein phosphatase-2A in lactacystin-induced tau accumulation
Mon May 01 00:00:00 UTC 2006
EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors.
Cancer research
Hu-Lieskovan S,Zhang J,Wu L,Shimada H,Schofield DE,Triche TJ
MA5-12805 was used in western blot to study whether EWS-FLI1 fusion gene expression is responsible for the primitive neuroectodermal phenotype of Ewing's family tumors
Wed Jun 01 00:00:00 UTC 2005
Nitration and oligomerization of tau induced by peroxynitrite inhibit its microtubule-binding activity.
FEBS letters
Zhang YJ,Xu YF,Chen XQ,Wang XC,Wang JZ
MA5-12805 was used in western blot to study the potential role of tau nitration in Alzheimer's pathology
Mon Apr 25 00:00:00 UTC 2005
Abnormal group I metabotropic glutamate receptor expression and signaling in the frontal cortex in Pick disease.
Journal of neuropathology and experimental neurology
Dalfó E,Albasanz JL,Rodríguez A,Martín M,Ferrer I
MA5-12805 was used in immunoprecipitation to study abnormal mGluR1 expression and signaling in the frontal cortex in Pick disease
Fri Jul 01 00:00:00 UTC 2005
Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia.
Brain : a journal of neurology
Stanford PM,Shepherd CE,Halliday GM,Brooks WS,Schofield PW,Brodaty H,Martins RN,Kwok JB,Schofield PR
MA5-12805 was used in western blot to study mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia
Tue Apr 01 00:00:00 UTC 2003
Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Patzke H,Maddineni U,Ayala R,Morabito M,Volker J,Dikkes P,Ahlijanian MK,Tsai LH
MA5-12805 was used in western blot to study the partial rescue of the Cdk5 adaptor protein p35 -/- phenotype by overexpression of a neronal-specific enolase p25 transgene
Tue Apr 01 00:00:00 UTC 2003
Rapid detection of protein aggregates in the brains of Alzheimer patients and transgenic mouse models of amyloidosis.
Alzheimer disease and associated disorders
Xu G,Gonzales V,Borchelt DR
MA5-12805 was used in western blot to develop a novel method for the rapid detection of beta-amyloid aggregates in Alzheimer's patients and transgenic mouse models
Wed Dec 04 00:00:00 UTC 2002
Hydrogen peroxide induces transient dephosphorylation of tau protein in cultured rat oligodendrocytes.
Neuroscience letters
LoPresti P,Konat GW
MA5-12805 was used in western blot to study the transient dephosphorylation of tau induced by hydrogen peroxide in rat oligodendrocytes
Fri Sep 28 00:00:00 UTC 2001
Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.
The Journal of biological chemistry
Kins S,Crameri A,Evans DR,Hemmings BA,Nitsch RM,Gotz J
MA5-12805 was used in western blot to study the role of protein phosphatase 2A activity in the hyperphosphorylation and compartmentalization of tau in transgenic mice
Fri Oct 12 00:00:00 UTC 2001
