Invitrogen

HOXB4 Polyclonal Antibody

HOXB4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HOXB4 Antibody (PA5-23366) in IHC (P)

Immunohistochemical analysis of HOXB4 in formalin-fixed, paraffin-embedded human brain tissue. Samples were incubated in HOXB4 polyclonal antibody (Product # PA5-23366) using a dilution of 5 µg/mL. Isotype control (top left) and this antibody (bottom left, right).

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产品信息

PA5-23366

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-3 µg/mL

免疫组化（石蜡） (IHC (P))

5 µg/mL

产品规格

种属反应

Mouse, Non-human primate, Rat, Bovine, Cat, Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A portion of amino acids 100-150 of human HOXB4

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 0.05% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2540889

靶标信息

HOX homeobox genes play a role both in the early stem cell function as well as in later stages of hematopoietic differentiation. HOXB4, specifically, is a homeotic selector gene implicated in self-renewal of definitive HSCs. Expression of HOXB4 in primitive progenitors combined with culture on hematopoietic stroma induced a switch to the definitive HSC phenotype. Activation of WNT signaling in HSCs induced increased expression of HOXB4. Perturbations of HOX gene expression can cause leukemia.

仅用于科研。不用于诊断过程。未经明确授权不得转售。