Invitrogen

GABA Polyclonal Antibody

GABA Antibody in Immunocytochemistry (ICC/IF)

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GABA Antibody (PA5-32241) in ICC/IF

Immunofluorescence analysis of GABA neurons using anti-GABA antibody (Product # PA5-32241). GABAergic precursor cells derived from H9 embryonic stem cells were differentiated for 7 days and stained with antibodies against GABA (Product # PA5-32241 at 1:5000) followed by Alexa Fluor 488 goat anti-rabbit (Product # A-21206, green) and neuronal marker beta III tubulin (Product # 480011 at 1:1000) followed by by Alexa Fluor 594 goat-anti-mouse (Product # A-11005, red). Nuclear DNA was stained with DAPI (blue).

GABA Antibody in Immunohistochemistry (Paraffin) (IHC (P))

GABA Antibody in Immunohistochemistry (Frozen) (IHC (F))

GABA Antibody in Immunohistochemistry (IHC)

Product Image Gallery

产品信息

PA5-32241

应用

建议稀释比

已发表文章

免疫组化 (IHC)

查看5篇已发表文章 5篇已发表文章

免疫组化（石蜡） (IHC (P))

1:100-1:1,000

免疫组化（冰冻） (IHC (F))

1:100-1:1,000

免疫细胞化学 (ICC/IF)

1:100-1:1,000

查看2篇已发表文章 2篇已发表文章

点杂交 (DB)

Assay-Dependent

产品规格

种属反应

Chemical

已发表种属

Chemical, Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

GABA conjugated to KLH

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.53 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2549714

产品详细信息

Recommended positive controls: GABA-conjugated BSA, mouse brain.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

This chemical acts as a neurotransmitter in the central nervous system. It reduces neuronal excitation and regulates muscle tone.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Genetic labeling reveals spatial and cellular expression pattern of neuregulin 1 in mouse brain.

Cell & bioscience

Ding CY,Ding YT,Ji H,Wang YY,Zhang X,Yin DM

PA5-32241 was used in Immunohistochemistry-immunofluorescence to reveal the cellular expression pattern of Nrg1 and axon projections of Nrg1-positive neurons in the rodent brain using CRISPR/Cas9 techniques, with the aim of understanding the diverse expression patterns of Neuregulin 1 (Nrg1) in different brain regions.

Fri May 05 00:00:00 UTC 2023

Pharmacotherapy alleviates pathological changes in human direct reprogrammed neuronal cell model of myotonic dystrophy type 1.

PloS one

Eltahir MK,Nakamori M,Hattori S,Kimura T,Mochizuki H,Nagano S

PA5-32241 was used in Immunocytochemistry to prove that our model is a promising tool for detailed pathogenetic examination and novel drug screening for the nervous system.

Thu Jul 07 00:00:00 UTC 2022

Raphe serotonin projections dynamically regulate feeding behavior through targeting inhibitory circuits from rostral zona incerta to paraventricular thalamus.

Molecular metabolism

Ye Q,Nunez J,Zhang X

PA5-32241 was used in Immunocytochemistry to reveal that raphe-ZIR 5-HT projections dynamically regulate ZIR GABA neurons for feeding control, supporting that a dynamic fluctuation of ZIR 5-HT inhibition authorizes daily food intake but a sustained change of ZIR 5-HT signaling leads to overeating induced by HFHS diet.

Thu Dec 01 00:00:00 UTC 2022

Chronic loss of inhibition in piriform cortex following brief, daily optogenetic stimulation.

Cell reports

Ryu B,Nagappan S,Santos-Valencia F,Lee P,Rodriguez E,Lackie M,Takatoh J,Franks KM

PA5-32241 was used in Immunohistochemistry to find no loss of inhibitory interneurons; rather, decreased GABA synthesis in feedback inhibitory neurons appears to underlie weakened inhibition.

Tue Apr 20 00:00:00 UTC 2021

Chronic loss of inhibition in piriform cortex following brief, daily optogenetic stimulation.

Cell reports

Ryu B,Nagappan S,Santos-Valencia F,Lee P,Rodriguez E,Lackie M,Takatoh J,Franks KM

PA5-32241 was used in Immunohistochemistry to find no loss of inhibitory interneurons; rather, decreased GABA synthesis in feedback inhibitory neurons appears to underlie weakened inhibition.

Tue Apr 20 00:00:00 UTC 2021

Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition.

Nature communications

Wang YY,Zhao B,Wu MM,Zheng XL,Lin L,Yin DM

PA5-32241 was used in Immunohistochemistry to identify mechanisms underlying cortical disinhibition related to schizophrenia and raise the possibility that restoration of NRG1 signaling and GABAergic function is beneficial in certain neuropsychiatric disorders.

Tue Jan 12 00:00:00 UTC 2021

Whole-Brain Monosynaptic Inputs to Hypoglossal Motor Neurons in Mice.

Neuroscience bulletin

Guo H,Yuan XS,Zhou JC,Chen H,Li SQ,Qu WM,Huang ZL

PA5-32241 was used in Immunohistochemistry to further elucidate the neural circuits underlying disorders caused by the dysfunction of hypoglossal motor neurons (HMNs).

Mon Jun 01 00:00:00 UTC 2020

Chemogenetic silencing of hippocampal neurons suppresses epileptic neural circuits.

The Journal of clinical investigation

Zhou QG,Nemes AD,Lee D,Ro EJ,Zhang J,Nowacki AS,Dymecki SM,Najm IM,Suh H

PA5-32241 was used in Immunohistochemistry to identify, using a mapping and neuronal manipulation method, newborn hippocampal dentate granule cells (DGCs) as an essential component of epileptic neural circuits.

Wed Jan 02 00:00:00 UTC 2019

生物信息学

蛋白别名: y-Aminobutyric acid

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GABA Polyclonal Antibody

GABA Antibody (PA5-32241) in ICC/IF

产品信息

PA5-32241

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

免疫组化（冰冻） (IHC (F))

免疫细胞化学 (ICC/IF)

点杂交 (DB)

种属反应

已发表种属

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

RRID

产品详细信息

靶标信息

生物信息学

性能保障

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