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产品信息
PR7358A
产品规格
种属
Human
Expression System
Insect cells
氨基酸序列
60-431
标签
GST-tag
分子量
69.7 kDa
分类
Recombinant
类型
Protein
偶联物
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
50mM tris, pH 7.5, with 0.5mM EDTA, 150mM NaCl, 2mM DTT, 50% glycerol, 0.02% Triton X-100
内含物
no preservative
保存条件
-80° C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Protein Form: Catalytic
靶标信息
SGK (SGK1) is a serine/threonine kinase that may be a transcriptional target for p38/MAPK in hepatoma cells. SGK plays an important role in cellular stress response and cell survival. SGK1 is transcriptionally activated by numerous stimuli, including serum, glucocorticoids, osmotic stress, and hormones. It phosphorylates and negatively regulates pro-apoptotic FOXO3A. SGK1 is thought to play an essential function in nephropathy and cardiovascular development.
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生物信息学
蛋白别名: serine/threonine protein kinase SGK; Serine/threonine-protein kinase Sgk1; Serum/glucocorticoid-regulated kinase 1; Sgk1 variant i3
基因别名: SGK; SGK1
UniProt ID: (Human) O00141
Entrez Gene ID: (Human) 6446
