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产品信息
PV4006
产品规格
种属
Human
Expression System
Insect cells
氨基酸序列
Full length
标签
GST-tag
分子量
64.2 kDa
分类
Recombinant
类型
Protein
偶联物
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
50mM tris, pH 7.5, with 150mM NaCl, 0.02% Triton X-100, 0.5mM EDTA, 2mM DTT, 50% glycerol
内含物
no preservative
保存条件
-80° C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Protein Form: Full Length
靶标信息
MAP2K3 (MEK3) is a dual-specificity protein kinase which acts in cellular signal transduction pathways, and is necessary for the expression of glucose transporter. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for MEK3.
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生物信息学
蛋白别名: Dual specificity mitogen-activated protein kinase kinase 3; EC 2.7.12.2; MAP kinase kinase 3; MAPK/ERK kinase 3; MAPKK 3; MEK 3; SAPK kinase 2; Stress-activated protein kinase kinase 2
基因别名: MAP2K3; MAPKK3; MEK3; MKK3; PRKMK3; SAPKK-2; SAPKK2; SKK2
UniProt ID: (Human) P46734
Entrez Gene ID: (Human) 5606
