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产品信息
A33509
产品规格
种属
Human
Expression System
Insect cells
氨基酸序列
1060-end
标签
GST-tag
分子量
88.9 kDa
分类
Recombinant
类型
Protein
偶联物
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
50mM tris HCl, pH 7.5, with 10mM glutathione, 0.1mM EDTA, 150mM NaCl, 0.1mM PMSF, 0.25mM DTT, 25% glycerol
内含物
no preservative
保存条件
-80° C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
This ALK T1151_L1152insT recombinant human protein (1060-end) was expressed in insect cells.
ALK T1151_L1152insT recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
Protein Form: Recombinant, Active, Catalytic
The gene accession number for ALK [T1151 is NP_004295.2.
靶标信息
ALK receptor tyrosine kinase or anaplastic lymphoma kinase was originally identified as a member of the insulin receptor subfamily that acquires transforming capability when truncated and fused to NPM (nucleophosmin) in the t(2;5) chromosomal rearrangement associated with ALCL. Many chromosomal rearrangements leading to enhanced ALK activity have been described and are implicated in a number of cancer types. In the nervous system, ALK in the presence of ligand appears essential for axonal guidance, whereas in the absence of ligand, ALK expression can lead to developmental neuronal apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ALK; ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246; CD246 antigen; mutant anaplastic lymphoma kinase
基因别名: ALK; CD246; NBLST3
UniProt ID: (Human) Q9UM73
Entrez Gene ID: (Human) 238
