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Highest antigen sequence indentity to the following orthologs: Mouse (84%), Rat (84%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-51579. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Activating signal cointegrator 1 complex subunit 2; ASC-1 complex subunit P100; Trip4 complex subunit p100
基因别名: ASC1P100; ASCC2; p100; RQT3
UniProt ID: (Human) Q9H1I8
Entrez Gene ID: (Human) 84164