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产品信息
PEP-253
产品规格
分类
Synthetic
类型
Peptide
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
PEP-253 is a 17 amino acid synthetic peptide corresponding to amino acid residues 92-107 from human ATR/TEM8. The sequence of this peptide is (amino to carboxy terminus): L-M-K-L-T-E-D-R-E-Q-I-R-Q-G-L-E-C.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product, catalog # PA1-602. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
靶标信息
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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