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产品信息
RP-98886
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
VSEPTTVAFDVRPGGVVHSFSHNVGPGDKYTCMFTYASQGGTNEQWQMSLGTSEDHQHFTCTIWRPQGKSY
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
1M urea/PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (90%), Rat (90%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-59766. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
The interleukins are a broad family of well characterized cytokines, primarily of hematopoietic cell origin. Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. IL-25 (also called SF20/IL-25) is a secreted bone marrow stroma-derived growth factor cytokine that is derived from Th2 T-cells. IL-25 belongs to the IL-17 cytokine family and is capable of amplifying allergic type inflammatory responses by its actions on other cell types. IL-25 binds to mouse thymic shared antigen-1 and supports lymphoid cell proliferation. Infusion of mice with IL-25 induces IL-4, IL-5, and IL-13 gene expression. IL-25 induced mice also develop epithelial cell hyperplasia, increased mucus secretion, and airway hyperreactivity, suggesting that IL-25 may be an important mediator of allergic disease via production of IL-4, IL-5, IL-13 and eotaxin.
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生物信息学
蛋白别名: CS010; IL 25; IL 27; interleukin 25; interleukin 27 working designation; interleukin-25; Interleukin25; MYDGF; Myeloid-derived growth factor; R33729 1; R337291; stromal cell-derived growth factor SF20; UPF0556 protein C19orf10
基因别名: C19orf10; EUROIMAGE1875335; IL25; IL27; IL27w; MYDGF; R33729_1; SF20
UniProt ID: (Human) Q969H8
Entrez Gene ID: (Human) 56005
