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Highest antigen sequence indentity to the following orthologs: Mouse (61%), Rat (61%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-56758. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
CAZIP, also known as TIP150, contains a leucine-zipper domain at the C-terminus and has at least three isoforms. CAZIP is expressed in heart during early cardiac development and in parts of the nervous system in later embryonic development. It is thought to bind microtubules and facilitate the end-binding protein 1 (EB1)-dependent loading of MCAK onto microtubules plus ends and orchestrates the dynamics at the plus end of microtubules. CAZIP may regulate the dynamics of microtubules at their growing distal tip.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: +TIP of 150 kDa; Cardiac zipper protein; Microtubule plus-end tracking protein TIP150; Microtubule-associated tumor suppressor candidate 2; RP11-274A8.2; Tracking protein of 150 kDa
基因别名: CAZIP; ICIS; KIAA0774; MTUS2; TIP150
UniProt ID: (Human) Q5JR59
Entrez Gene ID: (Human) 23281