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产品信息
PEP-0894
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
Unconjugated
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 17 amino acids near the amino terminus of human CCDC134.
PEP-0894 can be used as a blocking peptide with polyclonal antibody PA5-20780.
靶标信息
The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. One such protein is CCDC134, a recently identified secretory protein that has been found to inhibit the transcriptional activity of the Elk1 protein. Overexpression CCDC134 also inhibited the phosphorylation of Erk and JNK/SAPK but not p38 MAPK, while specific siRNA against CCDC134 activated Elk1 transcriptional activity and the phosphorylation of Erk and JNK/SAPK, suggesting a potential inhibiting role of CCDC134 in MAPK-mediated Elk1 transcription. CCDC134 is widely expressing in normal adult tissues, tumors, and cell lines.
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生物信息学
蛋白别名: Coiled-coil domain-containing protein 134; dJ821D11.3
基因别名: CCDC134
UniProt ID: (Human) Q9H6E4
Entrez Gene ID: (Human) 79879
