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Highest antigen sequence indentity to the following orthologs: Mouse (100%), Rat (100%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-58472. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CDC42 small effector protein 2; non-kinase Cdc42 effector protein SPEC2; Small effector of CDC42 protein 2
基因别名: CDC42SE2; SPEC2
UniProt ID: (Human) Q4KMT9
Entrez Gene ID: (Human) 56990