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Highest antigen sequence indentity to the following orthologs: Mouse (40%), Rat (40%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-140296. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 2310076E16Rik; Cardiomyopathy-associated protein 5; Dystrobrevin-binding protein 2; Genethonin-3; Myospryn; SPRY domain-containing protein 2; tripartite motif-containing 76; Tripartite motif-containing protein 76
基因别名: C5orf10; CMYA5; DTNBP2; SPRYD2; TRIM76
UniProt ID: (Human) Q8N3K9
Entrez Gene ID: (Human) 202333