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Highest antigen sequence indentity to the following orthologs: Mouse (84%), Rat (84%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-81971. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: cAMP response element modulator; cAMP-responsive element modulator; CREM 2alpha-b protein; CREM 2beta-a protein; ICER; Inducible cAMP early repressor; inducible cAMP early repressor ICER; MGC111110; MGC17881; MGC41893; OTTHUMP00000019443
基因别名: CREM; CREM-2; hCREM-2; ICER
UniProt ID: (Human) Q03060
Entrez Gene ID: (Human) 1390