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产品信息
300-28G-10UG
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKGR REEKVGKKEK IGKKKRQKKR KAAQKRKN
分子量
11.6 kDa
分类
Recombinant
类型
Protein
纯度
≥98% by SDS-PAGE gel and HPLC analyses.
内毒素浓度
<1 EU/µg
活性
Determined by its ability to chemoattract human T cells.
偶联物
形式
Lyophilized
纯化类型
purified
内含物
no preservative
保存条件
-20°C
运输条件
Ambient
产品详细信息
Recombinant Human CXCL12 (SDF-1g) is a 11.6 kDa protein containing 98 amino acid residues.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
靶标信息
The SDF-1 proteins are stromal-derived CXC chemokines that signal primarily through the CXCR4 receptor. SDF-1 proteins exert chemotactic activity over a broad range of immune system cell types and may also be involved in other processes including metastasis of certain cancers, inflammation, and angiogenesis. Additionally, SDF-1 can suppress HIV entry into cells expressing the CXCR4 receptor. Five isomers of SDF-1 have been found with SDF-1alpha being the predominant form, expressing in a wide range of cell types. The SDF-1gamma isoform is distinctive in that it contains a highly basic C-terminal region, which presumably is the reason for its high binding affinity to gylcosaminoglycans (GAG) and heparin sulfate (HS). Consequently, most of SDF-1gamma exists in a cell- and membrane-bound form, which confers greater stability compared to other isoforms via increased resistance to proteolytic degradation. SDF-1gamma binds with reduced affinity to the CXCR4 receptor when compared to the alpha and beta isoforms, but because of its increased stability can, over time, exert equal or greater activity when compared to other SDF-1 isoforms. SDF-1gamma expression has been found primarily in the heart (human and mouse) and in the brain and central nervous system (rat).
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生物信息学
蛋白别名: C-X-C motif chemokine 12; chemokine (C-X-C motif) ligand 12; Intercrine reduced in hepatomas; IRH; PBSF; Pre-B cell growth-stimulating factor; SDF-1; Stromal cell-derived factor 1; Stromal-Cell Derived Factor-1
基因别名: CXCL12; IRH; PBSF; SCYB12; SDF1; SDF1A; SDF1B; TLSF; TPAR1
UniProt ID: (Human) Q5IT36
Entrez Gene ID: (Human) 6387
