Search Thermo Fisher Scientific
Highest antigen sequence indentity to the following orthologs: Mouse (100%), Rat (100%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-62242. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Down-regulator of transcription 1; down-regulator of transcription 1, TBP-binding (negative cofactor 2); NC2-beta; negative cofactor 2; negative cofactor 2 beta; Negative cofactor 2-beta; Protein Dr1; TATA-binding protein-associated phosphoprotein
基因别名: DR1; NC2; NC2-BETA; NC2B
UniProt ID: (Human) Q01658
Entrez Gene ID: (Human) 1810