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产品信息
PHC2054
应用
建议稀释比
已发表文章
产品规格
种属
Human
已发表种属
Human,
Mouse
Expression System
CHO cells
氨基酸序列
APPRLICDSR VLERYLLEAK EAENITTGCA EHCSLNENIT VPDTKVNFYA WKRMEVGQQA VEVWQGLALL SEAVLRGQAL LVNSSQPWEP LQLHVDKAVS GLRSLTTLLR ALGAQKEAIS PPDAASAAPL RTITADTFRK LFRVYSNFLR GKLKLYTGEA CRTGDR
分子量
30.4 kDa
分类
Recombinant
类型
Protein
纯度
>98% by SDS-PAGE
内毒素浓度
<0.1 ng/µg
活性
Specific Activity = 150,000 IU/mg; determined by measuring normocythaemic mice.
偶联物
形式
Lyophilized
纯化类型
purified
保存液
0.006mg citric acid/0.59mg sodium citrate with 0.58mg NaCl
内含物
no preservative
保存条件
-20°C
运输条件
Wet ice (domestic); Wet or Dry ice (international)
产品详细信息
Carrier-Free
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile, deionized water to a concentration of 12,000-120,000 IU/mL. Further dilutions can be made in aqueous buffers. For long term storage, EPO solutions should be supplemented with carrier protein, such as 0.1% HSA or BSA.
Storage: This lyophilized preparation is stable at room temperature for three weeks, but should be stored desiccated below -18°C. Upon reconstitution, the preparation is stable for up to one week at 2°C to 8°C, but should be stored below -18°C for long term storage. Avoid repeated freeze/thaw cycles.
靶标信息
Erythropoietin (EPO) protein is a growth factor essential for the survival, proliferation, and differentiation of erythroid precursors. EPO is not responsible for early commitment to the lineage, and instead induces the final maturation of partially differentiated erythroid cells and the production of red cell-specific proteins, such as hemoglobin. The EPO receptor (EPOR) is present in higher levels on precursor cells, and expression diminishes with cell maturation.Hepatocytes are the main source of EPO in the fetus, followed by interstitial cells of the kidney after birth and through adulthood. EPO expression is upregulated during hypoxia, and low levels of transcription have also been detected in lung and brain tissue under these conditions. Recent data suggest that EPO may also play a role in the protection of neuronal tissue from damage and initiation of repair.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: epoetin; Erythropoietin; MGC138142
基因别名: EP; EPO; MVCD2
UniProt ID: (Human) P01588
Entrez Gene ID: (Human) 2056
