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产品信息
PV4802
产品规格
种属
Human
Expression System
Baculovirus
氨基酸序列
204-433
标签
GST-tag
分类
Recombinant
类型
Protein
偶联物
形式
Liquid
浓度
See Label
纯化类型
purified
保存液
proprietary buffer
内含物
no preservative
保存条件
-80° C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
产品详细信息
Estrogen Related Receptor beta, Ligand Binding Domain (ERR beta-LBD) is a 54.29 kDa recombinant human protein (amino acids 204-433) expressed as a GST fusion protein in baculovirus-infected insect cells. ERR beta was expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator displacement studies.
Binding Domain, GST-Tagged, Recombinant Human
Protein Form: Ligand Binding Domain
靶标信息
ESRRB (steroid hormone receptor ERR2) plays a role in maintenance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation ESRRB interacts with KDM1A by directly binding to enhancer sites of ELF5 and EOMES and activates their transcription leading to self-renewal of trophoblast stem cells. ESSRB also regulates expression of multiple rod-specific genes and is required for survival of this cell type. Defects in the gene can cause deafness, autosomal recessive, 35 (DFNB35).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ERR beta-2; ERR-beta; ERRbeta; ERRbeta-2; Estrogen receptor-like 2; estrogen-related nuclear receptor beta; Estrogen-related receptor beta; nuclear receptor ERRB2; Nuclear receptor subfamily 3 group B member 2; orphan nuclear receptor; Steroid hormone receptor ERR2
基因别名: DFNB35; ERR2; ERRb; ERRB2; ESRL2; ESRRB; NR3B2
UniProt ID: (Human) O95718
Entrez Gene ID: (Human) 2103
