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Highest antigen sequence indentity to the following orthologs: Mouse (83%), Rat (83%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-145031. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
ESAM is a 55-kDa membrane protein composed of 2 extracellular Ig domains, a single transmembrane domain, and a 120 amino acid cytoplasmic domain. ESAM is related to members of the junctional adhesion molecule (JAM) family, and is expressed on endothelial cells and activated platelets. ESAM at endothelial tight junctions plays a role in the regulation of vascular permeability, in response to agents such as VEGF or extravasating neutrophils.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 2310008D05Rik; Endothelial cell-selective adhesion molecule; HUEL (C4orf1)-interacting protein; LP4791 protein
基因别名: ESAM; UNQ220/PRO246; W117m
UniProt ID: (Human) Q96AP7
Entrez Gene ID: (Human) 90952