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产品信息
PEP-0403
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 13 amino acids near the carboxy terminus of human Toso.
PEP-0403 can be used as a blocking peptide with polyclonal antibody PA5-20285.
靶标信息
Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FAIM3; Fas apoptotic inhibitory molecule 3; Fc mu receptor; IgM Fc fragment receptor; IgM Fc receptor; IgM FcR; Immunoglobulin mu Fc receptor; Regulator of Fas-induced apoptosis Toso
基因别名: FAIM3; FCMR; TOSO
UniProt ID: (Human) O60667
Entrez Gene ID: (Human) 9214
