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Highest antigen sequence indentity to the following orthologs: Mouse (85%), Rat (85%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-51647. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cadherin family member 7; cadherin ME5; cadherin-related family member 8; Cadherin-related tumor suppressor homolog; FAT tumor suppressor 1; Protein fat homolog; Protocadherin Fat 1
基因别名: CDHF7; CDHR8; FAT; FAT1; hFat1; ME5
UniProt ID: (Human) Q14517
Entrez Gene ID: (Human) 2195