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Highest antigen sequence indentity to the following orthologs: Mouse (45%), Rat (45%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-57972. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: F-box and WD-40 domain protein 12; F-box and WD-40 domain-containing protein 12; F-box only protein 35; F-box- and WD40-repeat-containing protein; F-box/WD repeat-containing protein 12
基因别名: FBW12; FBXO12; FBXO35; FBXW12
UniProt ID: (Human) Q6X9E4
Entrez Gene ID: (Human) 285231