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产品信息
PEP-1388
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 17 amino acids near the amino terminus of human FOXRED2.
PEP-1388 can be used as a blocking peptide with polyclonal antibody PA5-34345.
靶标信息
FOXRED2, also known as ERFAD, is an endoplasmic reticulum (ER) luminal flavoprotein which may function in ER associated degradation (ERAD). It has been proposed to bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation. Upon knockdown of FOXRED2, the degradation of the ERAD model substrate ribophorin 332 is delayed, and the overall level of polyubiquitinated cellular proteins is decreased. Defects in the related protein FOXRED1 are a cause of mitochondrial complex I deficiency (MT-C1D), suggesting the FOXRED2 may also play a role in MT-C1D.
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生物信息学
蛋白别名: Endoplasmic reticulum flavoprotein associated with degradation; ER flavoprotein associated with degradation; FAD-dependent oxidoreductase domain containing 2; FAD-dependent oxidoreductase domain-containing protein 2
基因别名: ERFAD; FOXRED2
UniProt ID: (Human) Q8IWF2
Entrez Gene ID: (Human) 80020
