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Highest antigen sequence indentity to the following orthologs: Mouse (81%), Rat (81%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-66128. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway (PubMed:25048963). Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 (PubMed:21543332, PubMed:24064211).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: McIdas protein; multiciliate cell differentiation 1; Multiciliate differentiation and DNA synthesis-associated cell cycle protein; Multicilin; Protein Idas
基因别名: IDAS; MCI; MCIDAS; MCIN
UniProt ID: (Human) D6RGH6
Entrez Gene ID: (Human) 345643