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产品信息
PHC0314
应用
建议稀释比
已发表文章
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T
分子量
15.8 kDa
分类
Recombinant
类型
Protein
纯度
>98% by SDS-PAGE
内毒素浓度
<0.1 ng/µg
活性
Determined by its ability to induce STAT3 activation in U87 cells.
偶联物
形式
Lyophilized
纯化类型
purified
保存液
10mM sodium phosphate, pH 7.5
内含物
no preservative
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Carrier-Free
Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile distilled water to a concentration of 0.1-1.0 mg/mL. Do not vortex. For extended storage, dilute the constituted protein in buffered solution containing carrier protein, such as PBS with 0.1% BSA. Apportion the diluted protein into working aliquots, and store at ≤-20°C to -80°C.
Storage: The lyophilized protein is stable at room temperature for 1 month, but should be kept at -20°C to -80°C for long-term storage, preferably desiccated. The reconstituted protein is stable at 2-8°C for up to 1 week. Working aliquots stored with a carrier protein are stable for at least 3 months at ≤-20°C to ≤-80°C. Avoid repeated freeze-thaw cycles.
靶标信息
Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IL-31; ILN; Interleukin; Interleukin-31
基因别名: IL-31; IL31
UniProt ID: (Human) Q6EBC2
Entrez Gene ID: (Human) 386653
