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产品信息
200-36A-10UG
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
MKIDTPQQGS IQDINHRVWV LQDQTLIAVP RKDRMSPVTI ALISCRHVET LEKDRGNPIY LGLNGLNLCL MCAKVGDQPT LQLKEKDIMD LYNQPEPVKS FLFYHSQSGR NSTFESVAFP GWFIAVSSEG GCPLILTQEL GKANTTDFGL TMLF
分子量
17.2 kDa
分类
Recombinant
类型
Protein
纯度
≥ 98% by SDS-PAGE gel and HPLC analyses.
内毒素浓度
<1 EU/µg
活性
Measured by its ability to induce IL-8 secretion by A431 human epidermoid carcinoma cells.
偶联物
形式
Lyophilized
纯化类型
purified
内含物
no preservative
保存条件
-20°C
运输条件
Ambient
产品详细信息
200-36A-1MG will be provided as 2 x 500 µg (200-36A-500UG).
Recombinant Human IL-36alpha is a 17.2 kDa protein containing 154 amino acid residues.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
靶标信息
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36alpha (IL-1F6), beta (IL-1F8), and gamma (IL-1F9). IL-36alpha is highly expressed in psoriatic plaques, as are IL-36beta and IL-36gamma, and is the only IL-1 family member found to be expressed by T cells, as well as monocytes and B cells. Primarily found in skin and lymphoid tissues, IL-36alpha is also found to a lesser extent in tissues of the fetal brain, trachea, stomach, and intestine. IL-36alpha signals through a combination of the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells, and the widely expressed IL-RAcP (IL-1 receptor accessory protein). IL-36alpha also functions as an agonist of NF-kappaB and MAPK pathways, and induces the production of proinflammatory cytokines and chemokines, including IL-6, IL-8, BD-2, and BD-3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FIL1 epsilon; IL-1 epsilon; IL-1F6; IL-1F6 (FIL-1-epsilon); Interleukin; interleukin 1; interleukin 1 family, member 6 (epsilon); interleukin 1, epsilon; Interleukin-1 epsilon; Interleukin-1 family member 6; Interleukin-36; Interleukin-36 alpha
基因别名: FIL1; FIL1(EPSILON); FIL1E; IL-1F6; IL1(EPSILON); IL1E; IL1F6; IL36A
UniProt ID: (Human) Q9UHA7
Entrez Gene ID: (Human) 27179
