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产品信息
PEP-0121
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 12 amino amino terminus of human ILP-2.
PEP-0121 can be used as a blocking peptide with polyclonal antibody PA5-19999.
靶标信息
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2. ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: baculoviral IAP repeat-containing 8; IAP-like protein 2; inhibitor of apoptosis-like protein 2; testis-specific inhibitor of apoptosis
基因别名: hILP2; ILP-2; ILP2
Entrez Gene ID: (Human) 112401
