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Invitrogen
Human IP3 Receptor 1 (aa 2472-2553) Control Fragment Recombinant Protein
产品信息
RP-91255
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
KDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSPAPREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRS
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
PBS/1M urea, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (91%), Rat (91%).
This recombinant protein control fragment may be used for blocking experiments. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Inositol 1,4,5 trisphosphate receptor; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate receptor, type 1; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; IP3 receptor; IP3 receptor isoform 1; IP3R 1; protein phosphatase 1, regulatory subunit 94; SI-SIII-SIIA; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
基因别名: ACV; CLA4; INSP3R1; IP3R; IP3R1; ITPR1; PPP1R94; SCA15; SCA16; SCA29
UniProt ID: (Human) Q14643
Entrez Gene ID: (Human) 3708
