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产品信息
RP-107990
产品规格
种属
Human
Expression System
E. coli
氨基酸序列
FPRQLLIRHFWTPKQQTDFLDIYHAFRKQSHPEIISYLEKVIPLISDAGLRWRLTDLCTKIQRG
标签
His-ABP-tag
分类
Recombinant
类型
Protein
纯度
>80% by SDS-PAGE and Coomassie blue staining
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
purified
保存液
1M urea/PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Highest antigen sequence indentity to the following orthologs: Mouse (59%), Rat (59%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-67341. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
靶标信息
HCCR-1 (human cervical cancer oncogene 1), also known as HCCR-2 or LETMD1, is a 360 amino acid single-pass membrane protein that is expressed in the kidney, liver, skeletal muscle, heart and brain. It is suggested that HCCR-1 may be involved in tumorigenesis and may function as a negative regulator of the p53 tumor suppressor. Overexpression of HCCR-1 may cause mitochondrial dysfunction that can lead to UVC or staurosporine-induced apoptosis resistance and progression of tumor formation. HCCR-1 is considered a candidate biomarker for breast cancer. Various human tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon, and uterine cervix have high HCCR-1. Six isoforms exist due to alternative splicing events.
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生物信息学
蛋白别名: Cervical cancer 1 proto-oncogene protein p40; Cervical cancer proto-oncogene 2 protein; HCCR-1; HCRR-2; LETM1 domain-containing protein 1; regulator of TP53
基因别名: 1110019O13Rik; HCCR-1; HCCR-2; HCCR1; HCRR-2; LETMD1
UniProt ID: (Human) Q6P1Q0
Entrez Gene ID: (Human) 25875
