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产品信息
PEP-1228
产品规格
种属反应
Human
分类
Synthetic
类型
Peptide
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
purified
保存液
PBS, pH 7.2, with 0.1% BSA
内含物
0.02% sodium azide
保存条件
-20°C
产品详细信息
This peptide corresponds to 19 amino acid peptide near the carboxy terminus of human LRRFIP1.
PEP-1228 can be used as a blocking peptide with polyclonal antibody PA5-21114.
靶标信息
Leucine-rich repeat FLI-I interacting protein 1 (LRRFIP1/FLAP-1) is a MyD88-interacting signal protein which mediates either induction or repression of TLR signaling. Flap-1 directly interacts with β-catenin and activates β-catenin-dependent transcription activity. Flap-1 or LRRFIP1 was also shown to bind the TNF- -308 promoter polymorphism site, suggesting its possible role in the regulation of TNF- production. FLAP-1 along with LRRFIP2 and FLIIH serve as a balance in coordinating inflammatory response after infection, and may act as a novel target in the control of agonist-induced TLR-mediated inflammatory and autoimmune diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GC-binding factor 2; HUFI1; leucine rich repeat (in FLII) interacting protein 1; Leucine-rich repeat flightless-interacting protein 1; LRR FLII-interacting protein 1; NEDD8-conjugating enzyme; TAR RNA-interacting protein
基因别名: FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2; HUFI-1; LRRFIP1; TRIP
UniProt ID: (Human) Q32MZ4
Entrez Gene ID: (Human) 9208
