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Highest antigen sequence indentity to the following orthologs: Mouse (81%), Rat (81%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-62342. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK6 activates the JNK, but not ERK or p38 kinase pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Apoptosis signal-regulating kinase 2; MGC125653; MGC20114; Mitogen-activated protein kinase kinase kinase 6; OTTHUMP00000005063
基因别名: ASK2; MAP3K6; MAPKKK6; MEKK6
UniProt ID: (Human) O95382
Entrez Gene ID: (Human) 9064