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Highest antigen sequence indentity to the following orthologs: Mouse (66%), Rat (66%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-57392. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Multimerin-1, also known as MMRN1, EMILIN-4 or ECM (endothelial cell multimerin), is a 1,228 amino acid secreted protein that contains one C1q domain, one EMI domain and one EGF-like domain. Synthesized in megakaryocytes and endothelial cells and present in liver, lung and placenta, Multimerin-1 exists as a multimeric structure composed of varying disulfide-linked multimers and functions as a carrier protein for platelet factors (specifically platelet factor V), playing a role in the stabilization and storage of factor V in platelets. In addition, Multimerin-1 acts as a ligand for select Integrins and may participate in extracellular matrix adhesion. Defects in the gene encoding Multimerin-1 that lead to Multimerin-1 deficiency are associated with autosomal dominant bleeding disorders due to platelet factor malfunction. Multiple isoforms of Multimerin-1 exist due to alternative splicing events.
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蛋白别名: Elastin microfibril interface located protein 4; Elastin microfibril interfacer 4; EMILIN-4; Endothelial cell multimerin; glycoprotein Ia*; Multimerin-1; p155
基因别名: ECM; EMILIN4; GPIA*; MMRN; MMRN1
UniProt ID: (Human) Q13201
Entrez Gene ID: (Human) 22915